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PUBLICATIONS

Publications

2020
Mucker EM, Karmali PP, Vega J, Kwilas SA, Wu H, Joselyn M, Ballantyne J, Sampey D, Mukthavaram R, Sullivan E, Chivukula P, Hooper JW; Lipid Nanoparticle Formulation Increases Efficiency of DNA-Vectored Vaccines/Immunoprophylaxis in Animals Including Transchromosomic Bovines, Scientific Reports,  29 May 2020, 10(1):8764

Casey C. Perley, Rebecca L. Brocato, Hua Wu, Christoph Bausch, Priya P. Karmali, Jerel B. Vega, Melanie V. Cohen, Brandon Somerville, Steven A. Kwilas, Lucia M. Principe, Joshua Shamblin, Padmanabh Chivukula, Eddie Sullivan and Jay W. Hooper; Anti-HFRS Human IgG Produced in Transchromosomic Bovines Has Potent Hantavirus Neutralizing Activity and Is Protective in Animal ModelsFrontiers in Microbiology, 07 May 2020

2019
H Wu, Z Fan, M Brandsrud, Q Meng, M Bobbitt, M Regouski, R Stott, A Sweat, J Crabtree, RJ Hogan, RA Tripp, Z Wang, IA Polejaeva, EJ Sullivan; Generation of H7N9-Specific Human Polyclonal Antibodies from a Transchromosomic Goat (caprine) System, In Scientific Reports, 2019 Jan 23; 9(1):366

V Siddharthan, J Miao, AJ Van Wettere, R Li, H Wu, E Sullivan, J Jiao, JW Hooper, D Safronetz, JD Morrey, JG Julander, Z Wang; Human Polyclonal Antibodies Produced from Transchromosomal Bovine Provides Prophylactic and Therapeutic Protections Against Zika Virus Infection in STAT2 KO Syrian Hamsters, In Viruses, 2019 Jan 22; 11(2):92

2018
Thomas Luke, Richard S Bennett, Dawn M Gerhardt, Tracey Burdette, Elena Postnikova, Steven Mazur, Anna N Honko, Nicholas Oberlander, Russell Byrum, Dan Ragland, Marisa St. Claire, Krisztina B Janosko, Gale Smith, Gregory Glenn, Jay Hooper, John Dye, Subhamoy Pal, Kimberly A Bishop-Lilly, Theron Hamilton, Kenneth Frey, Laura Bollinger, Jiro Wada, Hua Wu, Jin-an Jiao, Gene G Olinger, Bronwyn Gunn, Galit Alter, Surender Khurana, Lisa E Hensley, Eddie Sullivan, Peter B Jahrling; Fully Human Immunoglobulin G From Transchromosomic Bovines Treats Nonhuman Primates Infected With Ebola Virus Makona Isolate, The Journal of Infectious Diseases, jiy377

John H Beigel, MD John H Beigel, Jocelyn Voell, RN, Parag Kumar, PharmD, Kanakatte Raviprakash, PhD, Hua Wu, PhD, Jin-An Jiao, PhD, Eddie Sullivan, PhD, Thomas Luke, MD, Richard T Davey Jr, MD; Safety and tolerability of a novel, polyclonal human anti-MERS coronavirus antibody produced from transchromosomic cattle: a phase 1 randomised, double-blind, single-dose-escalation study, The Lancet Infectious Diseases, 2018/01/11

Jared N Silver, Cameron D Ashbaugh, Jacob J Miles, Hua Wu, Gregory T Marecki, Joyce K Hwang, Jin-An Jiao, Mark Abrams, Eddie J Sullivan, Duane R Wesemann; Deployment of Transchromosomal Bovine for Personalized Antimicrobial Therapy, Clinical Infectious Diseases, cix977

Sandra Fuentes, Supriya Ravichandran, Surender Khurana; Antibody Repertoire of Human Polyclonal Antibodies Against Ebola Virus Glycoproteins Generated After Deoxyribonucleic Acid and protein Vaccination of Transchromosomal Bovines, The Journal of Infectious Diseases, 2018; 218

2017
Derek R. Stein, Joseph W. Golden, Bryan D. Griffin, Bryce M. Warner, Charlene Ranadheera, Leanne Scharikow, Angela Sloan, Kathy L. Frost, Darwyn Kobasa, Stephanie A. Booth, Matthew Josleyn, John Ballantyne, Eddie Sullivan, Jin-an Jiao, Hua Wu, Zhongde Wang, Jay W. Hooper, David Safronetz; Human polyclonal antibodies produced in transchromosomal cattle prevent lethal Zika virus infection and testicular atrophy in mice, In Antiviral Research, Volume 146, 2017, Pages 164-173, ISSN 0166-3542

Gardner, Christina L., Sun, Chengqun, Luke, Thomas, Raviprakash, Kanakatte, Wu, Hua, Jiao, Jin-an, Sullivan, Eddie, Reed, Douglas S., Ryman, Kate D., Klimstra, William B.; Antibody preparations from human transchromosomic cows exhibit prophylactic and therapeutic efficacy versus Venezuelan equine encephalitis virus, 2017/05/03, Journal of Virology, 10.1128/JVI.00226-17

JH Tian, G Glenn, D Flyer, B Zhou, Y Liu, E Sullivan, H Wu, JF Cummings, L Ellingsworth, G Smith; Clostridium Difficile Chimeric Toxin Receptor Binding Domain Vaccine Induced Protection Against Different Strains in Active and Passive Challenge Models, In Vaccine, 2017; 35(33): 4079-4087

2016
Dye, John M., Wu, Hua, Hooper, Jay W., Khurana, Surender, Kuehne, Ana I., Coyle, Elizabeth M., Ortiz, Ramon A., Fuentes, Sandra, Herbert, Andrew S., Golding, Hana, Bakken, Russell A., Brannan, Jennifer M., Kwilas, Steve A., Sullivan, Eddie J., Luke, Thomas C., Smith, Gale, Glenn, Gregory, Li, Wenfang, Ye, Ling, Yang, Chinglai, Compans, Richard W., Tripp, Ralph A., Jiao, Jin-an; Production of Potent Fully Human Polyclonal Antibodies against Ebola Zaire Virus in Transchromosomal Cattle, Scientific Reports, 2016/04/25/online Volume 6, 24897

Thomas Luke, Hua Wu, Jincun Zhao, Rudragouda Channappanavar, Christopher M. Coleman, Jin-An Jiao, Hiroaki Matsushita, Ye Liu, Elena N. Postnikova, Britini L. Ork, Gregory Glenn, David Flyer, Gabriel Defang, Kanakatte Raviprakash, Tadeusz Kochel, Jonathan Wang, Wensheng Nie, Gale Smith, Lisa E. Hensley, Gene G. Olinger, Jens H. Kuhn, Michael R. Holbrook, Reed F. Johnson, Stanley Perlman, Eddie Sullivan, Matthew B. Frieman; Human polyclonal immunoglobulin G from transchromosomic bovines inhibits MERS-CoV in vivo, Science Translational Medicine, 2016; 8 (326): 326ra21 DOI: 10.1126/scitranslmed.3010082

T Luke, H Wu, J Zhao, R Channappanavar, CM Coleman, J Jiao, H Matsushita, Y Liu, EN Postnikova, BL Ork, G Glenn, D Flyer, G Defang, K Raviprakash, T Kochel, J Wang, W Nie, G Smith, LE Hensley, GG Olinger, JH Kuhn, MR Holbrook, RF Johnson, S Perlman, E Sullivan, MB Frieman; Human Antibody Produced from Transchromosomic Bovine Inhibits MERS CoV in Vivo, In Science Translational Medicine, 2016; 18:32ra21, PMID: 26888429

2015
Matsushita H, Sano A, Wu H, Wang Z, Jiao J-a, Kasinathan P, et al. (2015); Species-Specific Chromosome Engineering Greatly Improves Fully Human Polyclonal Antibody Production Profile in Cattle, PLoS ONE 10(6): e0130699.

CE Bounds, SA Kwilas, AI Kuehne, JM Brannan, RR Bakken, JM Dye, JW Hooper, LC Dupuy, B Ellefsen, D Hannaman, H Wu, JA Jiao, EJ Sullivan, CS Schmaljohn; Human Polyclonal Antibodies Produced Through DNA Vaccination of Transchromosomal Cattle Provide Mice With Post-Exposure Protection Against Lethal Zaire and Sudan Ebolaviruses, In PLoS One, 2015; 10(9): e0137786, PMID: 26422247

2014
J. W. Hooper, R. L. Brocato, S. A. Kwilas, C. D. Hammerbeck, M. D. Josleyn, M. Royals, J. Ballantyne, H. Wu, J.-a. Jiao, H. Matsushita, E. J. Sullivan; DNA vaccine-derived human IgG produced in transchromosomal bovines protect in lethal models of hantavirus pulmonary syndrome, Science Translational Medicine, 2014; 6 (264): 264ra162 DOI: 10.1126/scitranslmed.3010082

Matsushita H, Sano A, Wu H, Jiao JA, Kasinathan P, Sullivan EJ, Wang Z, Kuroiwa Y (2014); Triple Immunoglobulin Gene Knockout Transchromosomic Cattle: Bovine Lambda Cluster Deletion and Its Effect on Fully Human Polyclonal Antibody Production, PLoS ONE, 9(3): e90383. doi:10.1371/journal.pone.0090383

2013
Sano A, Matsushita H, Wu H, Jiao JA, Kasinathan P, Sullivan EJ, Wang Z, Kuroiwa Y. (2013); Physiological Level Production of Antigen-Specific Human Immunoglobulin in Cloned Transchromosomic Cattle, PLoS ONE, 8(10): e78119. doi:10.1371/journal.pone.0078119

2011
GE Liu, Y Hou, JM Robl, Y Kuroiwa, Z Wang; Assessment of Genome Integrity with Array CGH in Cattle Transgenic Cell Lines Produced by Homologous Recombination and Somatic Cell Cloning, In Genome Integrity, 2011 May 23; 2(1): 6 doi: 10.1186/2041-9414-2-6

2010
CA McLean, Z Wang, K Babu, A Edwards, P Kasinathan, J Robl, AM Sheppard; Normal Development Following Chromatin Transfer Correlates with Donor Cell Initial Epigenetic State, In Animal Reproduction Science, 2010 Apr; 118(2-4): 388-393

2009
Kuroiwa Y, Kasinathan P, Sathiyaseelan T, Jiao JA, Matsushita H, Sathiyaseelan J, Wu H, Mellquist J, Hammitt M, Koster J, Kamoda S, Tachibana K, Ishida I, Robl JM; Antigen-specific human polyclonal antibodies from hyperimmunized cattle, Nature Biotechnology, 2009 Feb; 27(2):173-81. Epub 2009 Jan 18.

N Rodriguez-Osorio, Z Wang, P Kasinathan, GP Page, JM Robl, E Memili; Transcriptional Reprogramming of Gene Expression in Bovine Somatic Cell Chromatin Transfer Embryos, In BMC Genomics, 2009 Apr 24; 10: 190

2008
Eddie J. Sullivan, Jerry Pommer and James M. Robl, Commercialising genetically engineered animal biomedical products, Reproduction, Fertility and Development, 2008, 20, 61–66.

2007
JM Robl, Z Wang, P Kasinathan, Y Kuroiwa; Transgenic Animal Production and Animal Biotechnology, In Theriogenology, 2007 Jan 1; 67(1): 127-133

JM Robl; Application of Cloning Technology for Production of Human Polyclonal Antibodies in Cattle, In Cloning Stem Cells, 2007 Spring; 9(1): 12-16

2006
Richt JA, Kasinathan P, Hamir AN, Castilla J, Sathiyaseelan T, Vargas F, Sathiyaseelan J, Wu H, Matsushita H, Koster J, Kato S, Ishida I, Soto C, Robl JM, Kuroiwa Y; Production of cattle lacking prion protein, Nature Biotechnology 2007 Jan;25(1):132-8. Epub 2006 Dec 31.

2005
DA Stringfellow, KP Riddell, MD Givens, PK Galik, E Sullivan, CC Dykstra, J Robl, P Kasinathan; Bovine Viral Diarrhea Virus (BVDV) in Cell Lines Used for Somatic Cell Cloning, In Theriogenology, 2005 Mar 1; 63(4): 1004-1013

2004
Yoshimi Kuroiwa, Poothappillai Kasinathan, Hiroaki Matsushita, Janaki Sathiyaselan, Eddie J. Sullivan, Makoto Kakitani, Kazuma Tomizuka, Isao Ishida & James M. Robl; Sequential targeting of the immunoglobulin u and prion protein genes in cattle, Nature Genetics 36, 775 – 780 (2004);Published online: 6 June 2004.

Eddie J. Sullivan, Sriranjani Kasinathan, Poothappillai Kasinathan, James M. Robl, and Philippe Collas; Cloned Calves from Chromatin Remodeled In Vitro, Biology of Reproduction 70, 146–153 (2004) DOI 10.1095/biolreprod.103.021220.

DC Faber, LB Ferre, J Metzger, JM Robl, P Kasinathan; Argo-economic Impact of Cattle Cloning, In Cloning Stem Cells, 2004; 6(2): 198-207

MD Givens, DA Stringfellow, CC Dykstra, KP Riddell, PK Galik, E Sullivan, J Robl, P Kasinathan, A Kumar, DW Boykin; Prevention and Elimination of Bovine Viral Diarrhea Virus Infections in Fetal Fibroblast Cells, In Antiviral Research, 2004 Nov; 64(2): 113-118

2003
J.M. Robl, P. Kasinathan, E. Sullivan, Y. Kuroiwa, K. Tomizuka, I. Ishidab; Artifical chromosome vectors and expression of complex proteins in transgenic animals, Theriogenology. 2003 Jan 1;59(1):107-13.

2002
Y. Kuroiwa, P. Kasinathan, Y.J. Choi, R. Naeem, K. Tomizuka, E.J. Sullivan, J.G. Knott, A. Duteau, R.A. Goldsby, B.A. Osborne, I. Ishida, J.M. Robl; Cloned transchromic calves producing human immunoglobulin, Nature Biotechnology 2002 Sep;20(9):889-94. Epub 2002 Aug 12.

J.G. Knott, P. Kasinathan, H. Wu, C.L. He, R.A. Fissore and J.M. Robl; Porcine Sperm Factor Supports Activation and Development of Bovine Nuclear Transfer Embryos, Biology of Reproduction 2002 Apr;66(4):1095-103.

2001
P. Kasinathan, J.G. Knott, A.R. Spell and J.M. Robl; A Comparison of Somatic Cell Nuclear Transfer with Fibroblasts of Different Genetic Origin, Theriogenology December 15, 2001.

P. Kasinathan, J.G. Knott, Z. Wang, D.J. Jerry and J.M. Robl; Production of calves from G1 fibroblasts, Nature Biotechnology 2001 Dec;19(12):1176-8.

P. Moreira, J. Bomar, J.M. Robl and P. Collas; Identification of A-Kinase Anchoring Protein AKAP95 as a Molecular Marker of Nuclear Reprogramming after Nuclear Transfer, Theriogenology

J.G. Knott, E.J. Sullivan, P. Kasinathan, C.L. He, H. Wu, J.M. Robl and R.A. Fissore; The Generation of a Functional IP3R-1 Knockout in Bovine Oocytes, Theriogenology

P. Kasinathan, J.G. Knott, P.N. Moreira, A.S. Burnside, D.J. Jerry and J.M. Robl; Effect of Fibroblast Donor Cell Age and Cell Cycle on Development of Bovine Nuclear Transfer Embryos In Vitro, Biology of Reproduction 2001 May;64(5):1487-93.

1998
JB Cibelli, SL Stice, PJ Golueke, JJ Kane, J Jerry, C Blackwell, FA Ponce de León, JM Robl; Cloned Transgenic Calves Produced from Nonquiescent Fetal Fibroblasts, In Science, 1998 May 22; 280(5367): 1256-1258